Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking
نویسندگان
چکیده
منابع مشابه
Divergent signalling mechanisms involved in insulin-stimulated GLUT4 vesicle trafficking to the plasma membrane.
4 Downes, C. P. (ed.) ( I 998) Special Lipid Signalling Issue Biochim. Biophys. Acta 1436, 1-264 5 De Camilli, P.. Emr, S. D., McPhenon, P. S. and Novick, P. ( 1996) Science 27 I, 1533I539 6 Lemmon. M. A., Falasca, M., Ferguson. K. M. and Schlessinger, J. ( 1997) Trends Cell Biol. 7, 237-242 7 Bottomley. M. 1.. Salim. K. and Panayatou, G. ( I 998) Biochim. Biophys. Acta 1436, 165I 83 8 Gaullier...
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AS160 (TBC1D4) is a known Akt substrate that is phosphorylated downstream of insulin action and that leads to regulated traffic of GLUT4. As GLUT4 vesicle fusion with the plasma membrane is a highly regulated step in GLUT4 traffic, we investigated whether AS160 and 14-3-3 interactions are involved in this process. Fusion was inhibited by a human truncated AS160 variant that encompasses the firs...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.5.2593